化工社化工社 化学情報印刷レポート · 研究参考用
Methyl chloroformate → N-cyclopropyl-2-[3-(3-thienyl)phenoxy]ethoxyacetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl chloroformate | HCID 6586 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Cyclopropylamine | HCID 69828 | — |
| 反応物 | 2-[3-(3-Thienyl)phenoxy]ethoxyacetic acid | HCID 19917129 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-cyclopropyl-2-[3-(3-thienyl)phenoxy]ethoxyacetamide | HCID 19917094 | — |
反応手順
0.36 g of 2-[3-(3-thienyl)phenoxy]ethoxyacetic acid was dissolved in 7 ml of tetrahydrofuran, and under ice cooling, 110 μl of methyl chloroformate and 200 μl of triethylamine were added. After the mixture was stirred with cooling for 30 minutes, 178 μl of cyclopropylamine was added. The mixture was stirred at room temperature for 1 hour, and then ethyl ether and water were added. The organic layer separated was worked up in a customary manner to give 0.31 g of N-cyclopropyl-2-[3-(3-thienyl)phenoxy]ethoxyacetamide as a pale yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05439932 |
| 出典データセット | uspto-grants-1995_08 |
| ORD ID | ord-130e8a5ac4f6486b881f46dc2c6c34f5 |
| 出典メモ | uspto-grants-1995_08 |