Ammonium Chloride → HCID 15341843, compound

HRID 1756224Notes

Reaction equation

HRID 1756224 reaction equation
[CH:1]1([CH2:4][C:5]2[C:6]([OH:16])=[C:7]([CH:12]=[CH:13][C:14]=2[OH:15])[C:8](OC)=[O:9])[CH2:3][CH2:2]1.[Cl-].[NH4+:18]>>[CH:1]1([CH2:4][C:5]2[C:6]([OH:16])=[C:7]([CH:12]=[CH:13][C:14]=2[OH:15])[C:8]([NH2:18])=[O:9])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 25517Ammonium ChlorideHCID 15341799HCID 15341799, compound

Product 1

HCID 15341843HCID 15341843, compound

Procedure

The compound of Example 15 is heated at 50° C. in a saturated ammonium chloride solution overnight. The reaction mixture is thoroughly extracted with ethyl acetate, and the solvent dried (Na2SO4) and evaporated in vacuo to afford the crude product. Chromatographic purification or silica gel using ethyl acetate/hexane (4:6) as eluant affords the product.

Workup

  1. extractionThe reaction mixture is thoroughly extracted with ethyl acetate
  2. dry with materialthe solvent dried (Na2SO4)
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-db74a783f605424bbdf7848ceb667343
Source dataset
uspto-grants-1995_08
Patent number
US05439937

Reaction notes

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