HCID 15341787, compound → HCID 22399587, compound

HRID 1756230Notes

Reaction equation

HRID 1756230 reaction equation
[CH:1]1([CH2:4][C:5]2[C:6]([OH:15])=[C:7]([CH:11]=[CH:12][C:13]=2[OH:14])[C:8]([NH2:10])=[O:9])[CH2:3][CH2:2]1.I[CH2:17][CH2:18][CH2:19][O:20][C:21]1[CH:36]=[CH:35][C:24]2[CH2:25][CH2:26][CH:27]([CH2:29][CH2:30][C:31]([O:33][CH3:34])=[O:32])[O:28][C:23]=2[C:22]=1[CH2:37][CH2:38][CH3:39]>C(OCC)(=O)C.CCCCCC>[NH2:10][C:8]([C:7]1[CH:11]=[CH:12][C:13]([O:14][CH2:17][CH2:18][CH2:19][O:20][C:21]2[CH:36]=[CH:35][C:24]3[CH2:25][CH2:26][CH:27]([CH2:29][CH2:30][C:31]([O:33][CH3:34])=[O:32])[O:28][C:23]=3[C:22]=2[CH2:37][CH2:38][CH3:39])=[C:5]([CH2:4][CH:1]2[CH2:3][CH2:2]2)[C:6]=1[OH:15])=[O:9]

Participants

4

Reactant 2

HCID 15341787HCID 15341787, compoundHCID 15341843HCID 15341843, compound

Product 1

HCID 22399587HCID 22399587, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The compound of Example 66 and the compound of Example 3 are coupled under the conditions outlined in Example 60. Chromatography of the crude phenolic ester on silica gel using ethyl acetate/hexane (3:7) as eluant affords the product.

Workup

  1. customaffords the product

Sources & evidence

ORD record
ord-ca81e6d6611746cc8d4cd4047fa83db1
Source dataset
uspto-grants-1995_08
Patent number
US05439937

Reaction notes

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