HCID 15341787, compound → HCID 15341848, compound

HRID 1756232Notes

Reaction equation

HRID 1756232 reaction equation
[OH:1][C:2]1[C:10]([CH2:11][CH:12]=[CH2:13])=[C:9]([OH:14])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].I[CH2:16][CH2:17][CH2:18][O:19][C:20]1[CH:35]=[CH:34][C:23]2[CH2:24][CH2:25][CH:26]([CH2:28][CH2:29][C:30]([O:32][CH3:33])=[O:31])[O:27][C:22]=2[C:21]=1[CH2:36][CH2:37][CH3:38]>>[NH2:6][C:4]([C:3]1[CH:7]=[CH:8][C:9]([O:14][CH2:16][CH2:17][CH2:18][O:19][C:20]2[CH:35]=[CH:34][C:23]3[CH2:24][CH2:25][CH:26]([CH2:28][CH2:29][C:30]([O:32][CH3:33])=[O:31])[O:27][C:22]=3[C:21]=2[CH2:36][CH2:37][CH3:38])=[C:10]([CH2:11][CH:12]=[CH2:13])[C:2]=1[OH:1])=[O:5]

Participants

3

Reactant 2

HCID 15341787HCID 15341787, compoundHCID 15341803HCID 15341803, compound

Product 1

HCID 15341848HCID 15341848, compound

Procedure

The compound of Example 20 and the compound of Example 3 are coupled as described in Example 60. Chromatographic purification of the crude phenolic ester on silica gel using ethyl acetate/hexane (3:7) as eluant affords the product.

Workup

  1. customChromatographic purification of the crude phenolic ester on silica gel
  2. customaffords the product

Sources & evidence

ORD record
ord-e085f5cc5ca0400e89e20fc580d2f44c
Source dataset
uspto-grants-1995_08
Patent number
US05439937

Reaction notes

Loading…