Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2,6-Dibromopyridine | HCID 12274 | — |
| Reactant | Methyl 3-Hydroxybenzoate | HCID 88068 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 15661719 | HCID 15661719 | 96.8% |
Reaction Steps
A solution of 2.37 g of 2,6-dibromopyridine and 1.52 g of 3-hydroxybenzoic acid methyl ester in 10 ml of dimethylformamide is mixed with 6.6 g of cesium carbonate and heated to 120° C. with stirring for 3 hours. The reaction mixture is filtered on diatomaceous earth, rewashed with dichloromethane and the filtrate is concentrated by evaporation in a vacuum. The residue is distilled on a bulb tube at 140°-150° C. and 0.04 mbar. 2.98 g of 3-(6-bromo-2-pyridyloxy)-benzoic acid methyl ester of melting point 68°-69° C. is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05440044 |
|---|
| Source dataset | uspto-grants-1995_08 |
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| ORD ID | ord-fb8bd01695044451ae2c6a37f0a081c3 |
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| Source note | uspto-grants-1995_08 |
|---|
