Sodium Hydroxide → HCID 15661729, compound

HRID 1756328Notes

Reaction equation

HRID 1756328 reaction equation
C([O:3][C:4](=[O:29])[CH2:5][CH2:6][CH2:7][NH:8][C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13](/[CH:17]=[CH:18]/[CH:19]([OH:28])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[N:12]=1)=[O:10])C.[OH-].[Na+]>CO>[OH:28][CH:19]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])/[CH:18]=[CH:17]/[C:13]1[N:12]=[C:11]([C:9]([NH:8][CH2:7][CH2:6][CH2:5][C:4]([OH:29])=[O:3])=[O:10])[CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15661727HCID 15661727, compound

Product 1

HCID 15661729HCID 15661729, compoundYield 62.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Under the conditions of example 2, 60 mg of 4-{6-[(1E)-(3RS)-3-hydroxy-1-undecenyl]-2-pyridylcarbonylamino}-butyric acid ethyl ester in 1.5 ml of methanol is saponified with 1.5 ml of 1 n sodium hydroxide solution and worked up. 35 mg of the title compound is obtained as colorless oil.

Sources & evidence

ORD record
ord-1aab69a54e7741689c333e1b47a8252a
Source dataset
uspto-grants-1995_08
Patent number
US05440044

Reaction notes

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