Sodium Hydroxide → HCID 19966464, compound

HRID 1756330Notes

Reaction equation

HRID 1756330 reaction equation
C[O:2][C:3](=[O:28])[CH2:4][CH2:5][CH:6]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12](/[CH:16]=[CH:17]/[CH:18]([OH:27])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[N:11]=1)[CH:7]=[O:8].[OH-].[Na+]>CO>[OH:27][CH:18]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])/[CH:17]=[CH:16]/[C:12]1[N:11]=[C:10]([NH:9][CH:6]([CH:7]=[O:8])[CH2:5][CH2:4][C:3]([OH:28])=[O:2])[CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86748883HCID 86748883, compound

Product 1

HCID 19966464HCID 19966464, compoundYield 69.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Under the conditions of example 2, 60 mg of 4-{6-[(1E)-(3RS)-3-hydroxy-1-undecenyl]-2-pyridylamino}-5-oxo-pentanoic acid methyl ester in 1.5 ml of methanol is saponified with 1.5 ml of 1 n sodium hydroxide solution and worked up. 40 mg of the title compound is obtained as colorless oil.

Sources & evidence

ORD record
ord-101dc58f0bed40d68a98673bc7226a4c
Source dataset
uspto-grants-1995_08
Patent number
US05440044

Reaction notes

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