Tetrabutylammonium Fluoride → HCID 19966471, compound

Participants

Reaction Conditions

Reaction Steps

914 mg of tetrabutylammonium fluoride is added to a solution of 500 mg of (5RS)-5-acetoxy-5-{3-[(1E,3E)-(5RS)-5-acetoxy-1,3-tridecadienyl]-phenyl}-pentan-1-ol-tert-butyldimethylsilylether in 28 ml of tetrahydrofuran at 0° C., stirred for 30 minutes at 0° C. and for 4.5 hours at 24° C. Then, it is diluted with ether, washed with brine, dried on sodium sulfate and concentrated by evaporation in a vacuum. The residue is chromatographed on silica gel. With hexane/0-20% ethyl acetate, 193 mg of (5RS)-5-acetoxy-5-{3-{(1E,3E)-(5RS)-5-acetoxy-1,3-tridecadienyl}-phenyl}-pentan-1-ol is obtained as colorless oil.

Provenance & Evidence