Acetic Anhydride → HCID 15661772, compound

HRID 1756344Notes

Reaction equation

HRID 1756344 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[OH:8][CH:9]([CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])/[CH:10]=[CH:11]/[CH:12]=[CH:13]/[C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([CH2:20][O:21][Si:22]([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23])[CH:15]=1>N1C=CC=CC=1>[C:1]([O:8][CH:9]([CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])/[CH:10]=[CH:11]/[CH:12]=[CH:13]/[C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([CH2:20][O:21][Si:22]([C:25]([CH3:26])([CH3:27])[CH3:28])([CH3:23])[CH3:24])[CH:15]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 15661770HCID 15661770, compound

Product 1

HCID 15661772HCID 15661772, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
23 °C

Procedure

For acetylation, 31 ml of acetic anhydride is added to a solution of 11 g of the above-produced alcohol in 120 ml of pyridine and stirred for 15 hours at 23° C. Then, it is concentrated by evaporation in a vacuum with adding toluene and the residue is chromatographed on silica gel. With hexane/0-3% ethyl acetate, 8.9 g of the title compound is obtained as colorless oil.

Workup

  1. concentrationThen, it is concentrated by evaporation in a vacuum with adding toluene
  2. customthe residue is chromatographed on silica gel

Sources & evidence

ORD record
ord-76c567effed946c1b0770cca9bc241ce
Source dataset
uspto-grants-1995_08
Patent number
US05440044

Reaction notes

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