Sodium Hydroxide → HCID 15658147, compound

HRID 1756355Notes

Reaction equation

HRID 1756355 reaction equation
[OH:1][CH:2]([C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([O:30]C)=[O:29])[CH:23]=1)[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6](/[CH:10]=[CH:11]/[CH:12]([OH:21])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[N:5]=1.[OH-].[Na+]>CO>[OH:1][CH:2]([C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([OH:30])=[O:29])[CH:23]=1)[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6](/[CH:10]=[CH:11]/[CH:12]([OH:21])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[N:5]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15658145HCID 15658145, compound

Product 1

HCID 15658147HCID 15658147, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Under the conditions of example 2, 30 mg of 2-[(2RS)-2-hydroxy-2-(3-methoxycarbonylphenyl)-ethyl]-6-[(1E)-(3RS)-3-hydroxy-1-undecenyl]-pyridine in 2 ml of methanol is saponified with 1 ml of 1 n sodium hydroxide solution and worked up. 18 mg of the title compound is obtained as oil.

Sources & evidence

ORD record
ord-fdadb7384b764afc99f67def870bc26c
Source dataset
uspto-grants-1995_08
Patent number
US05440044

Reaction notes

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