Sodium Hydroxide → HCID 19966480, compound

HRID 1756358Notes

Reaction equation

HRID 1756358 reaction equation
C[O:2][C:3](=[O:26])[CH2:4][CH2:5][C:6]#[C:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10](/[CH:14]=[CH:15]/[CH:16]([OH:25])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[N:9]=1.[OH-].[Na+]>CO>[OH:25][CH:16]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])/[CH:15]=[CH:14]/[C:10]1[N:9]=[C:8]([C:7]#[C:6][CH2:5][CH2:4][C:3]([OH:26])=[O:2])[CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67718090HCID 67718090, compound

Product 1

HCID 19966480HCID 19966480, compoundYield 57.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Under the conditions of example 2, 20 mg of 5-{6-[(1E)(3RS)-3-hydroxy-1-undecenyl]-2-pyridyl}-4-pentynoic acid methyl ester in 1 ml of methanol is saponified with 2 ml of 1 n sodium hydroxide solution and worked up. 11 mg of the title compound is obtained as yellow oil.

Sources & evidence

ORD record
ord-b2f9571e26374d98bf9f34a07accce3b
Source dataset
uspto-grants-1995_08
Patent number
US05440044

Reaction notes

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