反应详情

16 g (55.6 mmol) of the ester obtained above in (a) and 50 ml of ethyl alcohol are introduced into a round-bottomed flask. A solution of 2.5 g (58.5 mmol) of sodium hydroxide in 50 ml of water is added and the mixture is heated to reflux for one hour. The reaction medium is evaporated to dryness, the residue is taken up with water, the mixture is extracted with ethyl ether, the aqueous phase is separated after settling has taken place, acidified to pH 1 with concentrated hydrochloric acid and extracted with ethyl ether, and the organic phase is separated after settling has taken place, dried over magnesium sulphate and evaporated. 14 g (97%) of 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylglyoxylic acid are collected in the form of a colorless oil.

1. additionare introduced into a round-bottomed flask
2. temperaturethe mixture is heated
3. temperatureto reflux for one hour
4. customThe reaction medium is evaporated to dryness
5. extractionthe mixture is extracted with ethyl ether
6. customthe aqueous phase is separated after settling
7. extractionextracted with ethyl ether
8. customthe organic phase is separated after settling
9. dry with materialdried over magnesium sulphate
10. customevaporated
11. custom14 g (97%) of 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylglyoxylic acid are collected in the form of a colorless oil