HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → (-)-4-{[1-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)ethyloxy]carbonyl}benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Allyl 4-{[1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)ethyloxy]carbonyl}benzoate | HCID 21474484 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (-)-4-{[1-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)ethyloxy]carbonyl}benzoic acid | HCID 21474501 | — |
Reaction Steps
A solution of 2.40 g (5.71 mmol) of the ester obtained in Example 59 (b) in 30 ml of THF is treated with mg of tetrakis(triphenylphosphine)palladium(0) and 5 ml of morpholine under the preparation conditions of Example 24(b), to yield 1.94 g (89%) of the expected derivative, melting point 138° C. (αD =-53.2°; c=1, ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05439925 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-f19256d5c67f409487c22fdad229c852 |
| Source note | uspto-grants-1995_08 |