Glycine → HCID 54145171, compound

Participants

Reaction Steps

One hundred nineteen and three tenths parts of 1-(Hydroxymethyl) benzotriazole and glycine (30 parts) were added to 600 parts of dry toluene containing 1.7 parts of p-toluenesulfonic acid. The mixture was stirred and refluxed under a Dean-Stark trap. After about 4.5 hours, the theoretical amount of water (14.4 parts) had collected and heating was suspended. The reaction mixture was cooled in ice-water and the tan solid that had formed was filtered with suction. After washing the filter-cake consecutively with toluene and ether and drying it in vacuo, 116 parts of N,N-bis(benzotriazol-1-yl methyl) glycine were obtained and identified by 1H and 13C NMR spectral analysis. The product melted at 163°-6° C. and was obtained in 86% yield.

Provenance & Evidence