Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 2-Propen-1-yl 8-nitro-6-quinolinecarboxylate | HCID 19390582 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 19390591 | HCID 19390591 | 96.2% |
Reaction Steps
To a solution of 6-allyloxycarbonyl-8-nitroquinoline (4 g; 15.5 mM) in methanol (80 ml) was added SnCl2. (17.8 g-77.5 mM). The mixture was heated at 40° C. for 1 hour. After evaporation of the solvent, the residue was partitioned between an aqueous solution of NaHCO3 (10%) and ethyl acetate. The organic phase was concentrated and purified by subjecting to flash chromatography, eluting with ethylacetate/petroleum ether (30/70) to give 8-amino-6-allyloxycarbonylquinoline (3.4 g; 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05441949 |
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| Source dataset | uspto-grants-1995_08 |
|---|
| ORD ID | ord-90a86ea5f20b49d0b6f7d1f9fc424a1f |
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| Source note | uspto-grants-1995_08 |
|---|
