Ammonia → HCID 19967111, compound

HRID 1756518Notes

Reaction equation

HRID 1756518 reaction equation
S(=O)(=O)(O)O.[N+:6]([O-:9])(O)=[O:7].[CH3:10][CH:11]([CH3:24])[CH:12]([N:19]1[CH:23]=[CH:22][N:21]=[CH:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.N>>[CH3:10][CH:11]([CH3:24])[CH:12]([N:19]1[CH:23]=[CH:22][N:21]=[CH:20]1)[C:13]1[CH:18]=[CH:17][C:16]([N+:6]([O-:9])=[O:7])=[CH:15][CH:14]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 1118Sulfuric AcidHCID 67725263HCID 67725263, compound

Product 1

HCID 19967111HCID 19967111, compoundYield 97.8%

Procedure

To a stirred and cooled (0° C.) amount of 55.2 parts of sulfuric acid were added portionwise 13 parts of 1-(2-methyl-1-phenylpropyl)-1H-imidazole mononitrate. After stirring for 1/2 hour at 0° C., the reaction mixture was poured into ice-water. The whole was basified with ammonia and extracted with dichloromethane. The extract was dried, filtered and evaporated, yielding 12 parts (97.8%) of 1-[2-methyl-1-(4-nitrophenyl)-propyl]-1H-imidazole (interm. 40).

Workup

  1. stirringAfter stirring for 1/2 hour at 0° C.
  2. extractionextracted with dichloromethane
  3. customThe extract was dried
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-3c78716bda42400c8d643a44461c4af5
Source dataset
uspto-grants-1995_08
Patent number
US05441954

Reaction notes

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