反应详情

A solution of N-allyl-5-azaisatin (5.3 mmol), (Ph3P)3RhCl (0.5 mmol) in aqueous toluene is stirred under a nitrogen atmosphere at room temperature overnight. The organic layer is dried (MgSO4) and the solvent is evaporated. The residue is stirred in 1N HCl/MeOH for 15 min after which time the methanol is evaporated and the pH of the water is adjusted to 7. A precipitate is formed and purified by silica gel chromatography (1% MeOH:CHCl3) to obtain the title compound.

1. dry with materialThe organic layer is dried (MgSO4)
2. customthe solvent is evaporated
3. customis evaporated
4. customA precipitate is formed
5. custompurified by silica gel chromatography (1% MeOH:CHCl3)