HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isatin → 2,3-Dimethoxyindolo[2,1-b]quinazoline-6,12-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isatin | HCID 7054 | — |
| Reactant | 5-Chloroisatoic anhydride | HCID 78480 | — |
| Reactant | 5-Fluoroisatin | HCID 236566 | — |
| Reactant | 5,6-Dimethoxyisatoic anhydride | HCID 12762380 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2,3-Dimethoxyindolo[2,1-b]quinazoline-6,12-dione | HCID 478571 | 16% |
Reaction Steps
Using the procedure in Example 12, and substituting N-methylpyrrolidone (NMP) for N,N-dimethylformamide (DMF), 5,6-dimethoxyisatoic anhydride for 5-chloroisatoic anhydride and isatin for 5-fluoroisatin gave 367 mg (16%) of the title compound: mp 350° C. (dec); 1H NMR(CDCl3)δ 4.02-4.08 (d, 6H), 7.40-7.45 (m, 2H), 7.74-7.80 (m, 2H), 7.88-7.92 (m, 1H), 8.60-8.65 (d, 1H); MS (M+H)+ 308.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05441955 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-a8f428526e8340b5913d9845d9888c16 |
| Source note | uspto-grants-1995_08 |