HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromoisatin → 8-Bromoindolo[2,1-b]quinazoline-6,12-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromoisatin | HCID 6889 | — |
| Reactant | 5-Chloroisatoic anhydride | HCID 78480 | — |
| Reactant | 5-Fluoroisatin | HCID 236566 | — |
| Product | 8-Bromoindolo[2,1-b]quinazoline-6,12-dione | HCID 478572 | 9% |
Reaction Steps
Using the procedure in Example 12 and substituting isatoic anhydride for 5-chloroisatoic anhydride and 5-bromoisatin for 5-fluoroisatin gave the title compound in 9% yield: mp 288°-290.2° C.; 1H NMR (300 MHz, CDCl3) δ 8.56 (d, 1H) 8.44 (d, 1H) 8.06 (s, 1H) 8.04 (s, 1H) 7.82-7.96 (m, 2H) 7.66-7.76 (m, 1H); MS (M+H)+ 328.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05441955 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-faa0b8283f7c4b31b405c8958c5f3fea |
| Source note | uspto-grants-1995_08 |