5-Chloroisatoic anhydride → 7-Chloroindolo[2,1-b]quinazoline-6,12-dione

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Reaction Steps

Using the procedure in Example 12 and substituting isatoic anhydride for 5-chloroisatoic anhydride and 4-chloroisatin for 5-fluoroisatin gave the title compound in 16% yield: mp 294°-295.7° C.; 1H NMR (300 MHz, DMSO-d6) δ 8.49 (d, 1H) 8.33 (d, 1H) 7.97 (d, 2H) 7.81-7.90 (m, 1H) 7.72-7.80 (m, 1H) 7.52 (d, 1H); MS (M+H)+ 283.

Provenance & Evidence