2-Aminonicotinic acid → HCID 478657, compound

Participants

Reaction Steps

Using the procedure in Example 56 and substituting 2-aminobenzoic acid for 2-aminonicotinic acid and 5-carboethoxyisatin for 5-fluoroisatin gave the title compound in 30% yield: mp 270.5°-272.7° C.; 1H NMR (300 MHz, CDCl3) δ 8.71 (d, 1H) 8.59 (s, 1H) 8.42-8.54 (m, 2H) 8.05 (d, 1H) 7.84-7.94 (m, 1H) 7.66-7.76 (m, 1H) 4.38-4.5 (m, 2H) 1.4-1.5 (m, 3H).

Provenance & Evidence