Isatoic Anhydride → HCID 19390711, compound

HRID 1756581Notes

Reaction equation

HRID 1756581 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=O)[C:5]2=[O:12].[C:13]12[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=1)[NH:18]C(=O)O[C:14]2=[O:15].[F:25]C1C=C2NC(=O)OC(=O)C2=CC=1>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:25])[N:7]1[C:6](=[N:18][C:19]3[C:13]([C:14]1=[O:15])=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:5]2=[O:12]

Participants

4

Reactant 3

HCID 8359Isatoic AnhydrideHCID 2365665-FluoroisatinHCID 100581387-Fluoroisatoic anhydride

Product 1

HCID 19390711HCID 19390711, compoundYield 2%

Procedure

Using the procedure in Example 36 and substituting 5,6-difluoroisatin for 5-fluoroisatin and isatoic anhydride for 4-fluoroisatoic anhydride gave the title compound in 2% yield: mp >250° C. (dec); 1H NMR (300 MHz, DMSO-d6) δ 8.54 (dd, 1H) 8.42 (d, 1H), 8.25 (d, 1H), 7.9 (dd, 1H), 7.78-7.68 (q, 2H); MS (M+H)+ 285.

Sources & evidence

ORD record
ord-b867cb0dfb6c46b387fc2cea2a166a0c
Source dataset
uspto-grants-1995_08
Patent number
US05441955

Reaction notes

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