Hydrochloric Acid → HCID 19390688, compound

Participants

Reaction Steps

A solution of 8-carboethoxyindolo[2,1-b]quinazoline-6,12-dione (2 mmol, from Example 42) in 3 mL of trimethylsilyl iodide (TMSI) is heated to 100° C. for 4 h. The reaction mixture is cooled to room temperature, diluted with ether, and 3 mL of 0.5N NaOH solution is added. The reaction mixture is acidified with 6N HCl and extracted with chloroform. The chloroform extracts are dried, filtered, and concentrated to give 8-carboxyindolo[2,1-b]quinazoline-6,12-dione.

Provenance & Evidence