Lithium hydride → HCID 19390699, compound

Participants

Reaction Steps

A solution of 3-(N-t-butyloxycarbonylamino)-8-fluoroindolo[2,1-b]quinazoline-6,12-dione (0.5 mmol), (R)-glycidyl butyrate (0.55 mmol) and lithium hydride (0.60 mmol) in DMF is allowed to stir at room temperature overnight. The reaction mixture is diluted with CHCl3, washed with 0.1N HCl, sodium bicarbonate solution, dried (MgSO4) and the solvent is evaporated. Silica gel chromatography (1% MeOH/CHCl3) gives 3-(5-hydroxymethyloxazolidin-3-yl)-8-fluoroindolo[2,1-b]quinazoline-6,12-dione.

Provenance & Evidence