4-Toluenesulfonyl chloride → HCID 19390697, compound

Participants

Reaction Steps

A solution of 3-(5-hydroxymethyloxazolidin-3-yl)-8-fluoroindolo[2,1-b]-quinazoline-6,12-dione (0.1 mmol), tosyl chloride (0.12 mmol) and triethylamine (0.2 mmol) in dry DMF is allowed to stir at room temperature overnight. The reaction mixture is diluted with CHCl3, washed with 0.1N HCl, sodium bicarbonate solution, dried (MgSO4) and the solvent is evaporated to give 3-(5-tosyloxymethyloxazolidin-3-yl)-8-fluoroindolo[2,1-b]quinazoline-6,12-dione.

Provenance & Evidence