L-(+)-Cysteine → HCID 86748888, compound

HRID 1756624Notes

Reaction equation

HRID 1756624 reaction equation
[CH3:1][C:2]1[C:7]([OH:8])=[C:6]([CH:9]=[O:10])[C:5]([CH2:11][OH:12])=[CH:4][N:3]=1.Cl.[NH2:14][C@H:15]([C:18]([OH:20])=[O:19])[CH2:16][SH:17].[OH-].[Na+]>O>[CH3:1][C:2]1[N:3]=[CH:4][C:5]([CH2:11][OH:12])=[C:6]([CH:9]=[O:10])[C:7]=1[OH:8].[NH2:14][C@H:15]([C:18]([OH:20])=[O:19])[CH2:16][SH:17]

Participants

5

Reactant 3

HCID 5862L-(+)-CysteineHCID 6171Pyridoxal hydrochlorideHCID 14798Sodium Hydroxide

Product 1

HCID 86748888HCID 86748888, compoundYield 47.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Pyridoxal hydrochloride (2.7 g) and L-cysteine (1.6 g) were dissolved in water (40 ml). Thereto was dropwise added a 10% sodium hydroxide solution to make the pH 4.5. The mixture was left standing at a cool place to allow precipitation of white crystals. The crystals were collected by filtration and dissolved in 1N hydrochloric acid for recrystallization. The solution was adjusted to pH 5.0 with 1N sodium hydroxide to allow precipitation of white needle crystals. The crystals were collected by filtration, washed with water and dried under reduced pressure at 40° C. to give 1.8 g of pale yellow crystals, m.p. 135° C. (decomposition).

Workup

  1. waitThe mixture was left
  2. customprecipitation of white crystals
  3. filtrationThe crystals were collected by filtration
  4. dissolutiondissolved in 1N hydrochloric acid for recrystallization
  5. customprecipitation of white needle crystals
  6. filtrationThe crystals were collected by filtration
  7. washwashed with water
  8. customdried under reduced pressure at 40° C.

Sources & evidence

ORD record
ord-dda3efdabf5448bba677b06428a000e1
Source dataset
uspto-grants-1995_08
Patent number
US05441972

Reaction notes

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