反应详情

The mixture of 5-(1-methoxymethoxyethyl)-2-methylpyridine (21.0 g) and formalin (37% aq. HCHO, 14.1 g) was heated at 150° to 160° C. for 8 hours in a sealed tube. The reaction mixture was concentrated under reduced pressure and then the residue was subjected to silica gel column chromatography. A fraction eluted with chloroform-methanol (25:1, v/v) gave 2-[5-(1-methoxymethoxyethyl)-2-pyridyl]ethanol (7.8 g, yield: 32%) as oil.

1. temperaturewas heated at 150° to 160° C. for 8 hours in a sealed tube
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. washA fraction eluted with chloroform-methanol (25:1