Dimethylamine → HCID 19390895, compound

HRID 1756677Notes

Reaction equation

[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH2:11][C:12](=[O:20])[C:13]2[CH:18]=[CH:17][C:16](F)=[CH:15][CH:14]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[CH3:21][NH:22][CH3:23]>>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH2:11][C:12](=[O:20])[C:13]2[CH:18]=[CH:17][C:16]([N:22]([CH3:23])[CH3:21])=[CH:15][CH:14]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 674Dimethylamine

HCID 9970726HCID 9970726, compound

Product 1

HCID 19390895HCID 19390895, compound

Conditions

Temperature: 100 °C

Procedure

A mixture consisting of 3.2 g of 1-acetyl-4-[2-(4-fluorobenzoyl)ethyl]piperidine and 10 ml of 50% aqueous dimethylamine solution was heated at 100° C. with stirring for 6 hours and then worked up in the same manner as Example 37 to give 1.6 g of colorless crystals melting at 158°-160° C.

Sources & evidence

ORD record: ord-517d16440bdd4950b00807c5f3cf61ae
Source dataset: uspto-grants-1995_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05441967

Reaction notes

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