Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | HCID 10315149 | HCID 10315149 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 10000486 | HCID 10000486 | — |
Reaction Steps
To a solution of the 1-benzyl-4-[3-(4-fluorobenzoyl)propyl]piperidine (0.6 g) synthesized in 4) in dioxane (1 ml) was added 3 ml of pyrrolidine and the mixture was heated at 100° C. for 16 hours. Thereafter, the procedure of Example 37 was repeated to give 0.58 g of 1-benzyl-4-[3-(4-pyrrolidinobenzoyl]propyl]piperidine as colorless crystals melting at 115°-116° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05441967 |
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| Source dataset | uspto-grants-1995_08 |
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| ORD ID | ord-151381e749474660b4abfa511898cb82 |
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| Source note | uspto-grants-1995_08 |
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