Fumaric Acid → HCID 19390902, compound

HRID 1756682Notes

Reaction equation

[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][C:17](=[O:29])[C:18]2[CH:23]=[CH:22][C:21]([N:24]3[CH2:28][CH2:27][CH2:26][CH2:25]3)=[CH:20][CH:19]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:30]([OH:37])(=[O:36])/[CH:31]=[CH:32]/[C:33]([OH:35])=[O:34]>>[C:30]([OH:37])(=[O:36])/[CH:31]=[CH:32]/[C:33]([OH:35])=[O:34].[CH2:1]([N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][CH2:15][CH2:16][C:17](=[O:29])[C:18]2[CH:19]=[CH:20][C:21]([N:24]3[CH2:28][CH2:27][CH2:26][CH2:25]3)=[CH:22][CH:23]=2)[CH2:12][CH2:13]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 444972Fumaric Acid

HCID 10000486HCID 10000486, compound

Product 1

HCID 19390902HCID 19390902, compoundYield 100.2%

Procedure

The above 1-benzyl-4-[3-(4-pyrrolidinobenzoyl)propyl]piperidine (0.55 g) was treated with one equivalent of fumaric acid (0.16 g) and the reaction product was recrystallized from ethanol to give 0.7 g of 1-benzyl-4-[3-(4-pyrrolidinobenzoyl)propyl]piperidine fumarate as colorless crystals melting at 220°-222° C.

Workup

customthe reaction product was recrystallized from ethanol

Sources & evidence

ORD record: ord-8861bbe88805485e869a80fc71d09529
Source dataset: uspto-grants-1995_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05441967

Reaction notes

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