Fumaric Acid → HCID 19390835, compound

HRID 1756684Notes

Reaction equation

[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][CH2:17][C:18](=[O:30])[C:19]2[CH:24]=[CH:23][C:22]([N:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)=[CH:21][CH:20]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35]>>[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35].[CH2:1]([N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][CH2:15][CH2:16][CH2:17][C:18](=[O:30])[C:19]2[CH:20]=[CH:21][C:22]([N:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)=[CH:23][CH:24]=2)[CH2:12][CH2:13]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 444972Fumaric Acid

HCID 19390836HCID 19390836, compound

Product 1

HCID 19390835HCID 19390835, compoundYield 95.5%

Procedure

The 1-benzyl-4-[4-(4-pyrrolidinobenzoyl)butyl]piperidine (0.5 g) prepared in 5) was treated with one equivalent of fumaric acid (0.14 g) and the reaction product was crystallized from ethanol to give 0.6 g of 1-benzyl-4-[4-(4-pyrrolidinobenzoyl)butyl]piperidine fumarate as colorless crystals melting at 183°-185° C.

Workup

customthe reaction product was crystallized from ethanol

Sources & evidence

ORD record: ord-32552696f12f4993aa41dc06aec819bc
Source dataset: uspto-grants-1995_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05441967

Reaction notes

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