Acetic Acid → HCID 131719086, compound

Participants

Reaction Steps

The above-titled compound was prepared substantially in accordance with the procedure described in Example 6A using 5.2 g (18.5 mmol) of 3,5-bis(1,1-dimethylethyl)-4-(methoxymethoxy) benzylamine (prepared substantially in accordance with the procedures described in Example 1), 3.86 g (25.4 mmol) of N-phenylthiourea, 1.11 g (18.5 mol) of acetic acid and 180 ml of toluene. Such reaction provided 4.55 g of N[[3,5-bis(1,1-dimethylethyl)-4-(methoxymethoxy]phenyl]methyl]-N'-phenylthiourea. The methoxymethyl hydroxy protecting group was then removed, substantially in accordance with the procedure described in Example 6B, to provide 790 mg of title compound. m.p. 176°-179° C.

Provenance & Evidence