Triethylamine → HCID 19390813, compound

Participants

Reaction Steps

2-(5-Benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-yl)-N-[3,3-difluoro-1-isopropyl-2-hydroxy-3-[N-(tert-butoxycarbonylmethyl)carbamoyl]propyl]acetamide. To a solution of the product described at Example 1.b. (1.05 g) in tetrahydrofuran (17 mL) was added triethylamine (0.82 mL) and glycine tert-butylester hydrochloride (0.990 g). After 18 hours, additional triethylamine (0.30 mL) and glycine tert-butylester hydrochloride (0.33 g) were added. The additions were repeated after 1 day, and the reaction mixture stirred for 1 day. The mixture was evaporated and the solids were triturated with water, collected by filtration, washed (water, ether, hexane), and dried under vacuum to yield the title compound as a white powder; TLC: Rf =0.47, chloroform:methanol (97:3); m/z=672(M+1).

Provenance & Evidence