Chloroform → HCID 19390781, compound

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Reaction Steps

2-(5-Benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-yl)-N-[3,3-difluoro-1-isopropyl-2-oxo-3-[N-[2-(4-pyridyl)ethyl)carbamoyl]propyl]acetamide. The compound described in part a. was subjected to conditions similar to those described in Example 1. Multiple use of chromatography (first column) with chloroform:methanol (gradient, 97:3, 94:6), (second column) chloroform:methanol (98:2), (chromatotron-2 mm plate: flow 6 mL/min) dichloromethane:methanol (gradient, 98:2, 96:4) yielded the title compound; TLC: Rf =0.21, dichloromethane:methanol (97:3); MS: m/z=661(M+1). Analysis for C34H34F2N6O6.0.7 H2O: Calculated: C, 60.65; H, 5.30; N, 12.48; Found: C, 60.62; H, 5.24; N, 12.39. This product is also a Compound of the invention.

Provenance & Evidence