Water → HCID 54450288, compound

Participants

Reaction Steps

To a suspension of 1.26 g (33 mmol) of lithium aluminum hydride (LiAlH4) in 50 ml of tetrahydrofuran (THF) was dropwise added 5.01 g (20 mmol) of 2-(2, 3-methylenedioxyphenyl)heptanoic acid under water cooling. The reaction mixture was stirred at room temperature for 3 hours, and 1.26 ml of water, 1.26 ml of 15% aqueous sodium hydroxide and 3.78 ml of water were added in this order. After 50 ml of ethyl ether was added, the mixture was stirred, and precipitated white solid was filtered off. The filtrate was concentrated in vacuo to give 4.65 g of 2-(2, 3-methylenedioxyphenyl)heptanol as an oil.

Provenance & Evidence