Sodium Hydroxide → HCID 54057846, compound

Participants

Reaction Steps

To a solution of 1.49 g (3.94 mmol) of 2-(2, 3-methylenedioxyphenyl)heptylmalonic acid diethylester in 10 ml of ethanol was added 6.6 g of 10% aqueous sodium hydroxide, and the resultant mixture was refluxed under heating for 2.5 hours. The reaction mixture was concentrated in vacuo, mixed with 5 ml of water and 0.8 ml of conc. sulfuric acid and refluxed under heating for 4 hours. After cooling, the reaction mixture was shaken with ethyl acetate, and the extract was washed with saturated saline, dried over anhydrous magnesium sulfate and the solvent evaporated. The residue was chromatographed on a silica gel column, eluting with ethyl acetate/hexane (1/2) to give 0.92 g of 4-(2, 3-methylenedioxyphenyl) nonanoic acid as an oil.

Provenance & Evidence