1-Phenethylamine, (-)- → HCID 10422214, compound

HRID 1756781Notes

Reaction equation

HRID 1756781 reaction equation
[CH2:1]1[O:9][C:8]2[C:3](=[C:4]([CH:10]([CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:11]([OH:13])=[O:12])[CH:5]=[CH:6][CH:7]=2)[O:2]1.C1([C@@H](N)C)C=CC=CC=1>>[CH2:1]1[O:9][C:8]2[C:3](=[C:4]([C@@H:10]([CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:11]([OH:13])=[O:12])[CH:5]=[CH:6][CH:7]=2)[O:2]1

Participants

3

Reactant 2

HCID 758181-Phenethylamine, (-)-HCID 10354725HCID 10354725, compound

Product 1

HCID 10422214HCID 10422214, compound

Procedure

A salt obtianed from (±)-2-(2, 3-methylenedioxyphenyl) heptanoic acid and (S) -1phenylethylamine was three times recrystallized from a mixed solvent of ethyl acetate-heptane (1:9). This salt was treated with hydrochloric acid and extracted with ethylene chloride. The organic layer was washed with dilute hydrochloric acid, dried over anhydrous magnesium sulfate and the solvent evaporated to give (R )-(2, 3-methylenedioxyphenyl) heptanoic acid. Yield, 39%.

Workup

  1. customrecrystallized from a mixed solvent of ethyl acetate-heptane (1:9)
  2. additionThis salt was treated with hydrochloric acid
  3. extractionextracted with ethylene chloride
  4. washThe organic layer was washed with dilute hydrochloric acid
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customthe solvent evaporated

Sources & evidence

ORD record
ord-67fc95c401874f538934f39f235d9c34
Source dataset
uspto-grants-1995_08
Patent number
US05442060

Reaction notes

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