Pyridine → HCID 86748893, compound

Participants

Reaction Steps

To a mixture of 0.42 g of 5-amino-4, 6-di (1-methylethoxy) pyrimidine, 0.30 g of pyridine and 8 ml of methylene chloride was dropwise added 0.26 g of ethyl chloroformate at room temperature with stirring, and the resultant mixture was stirred for 5 hours. The reaction mixture was washed with water and saturated saline in order, dried over anhydrous sodium sulfate and the solvent evaporated. The residue was chromatographed on a silica gel column, eluting with ethyl acetate-n-hexane (1:5) to give 0.29 g of 4, 6-di (1-methylethoxy)-5-ethoxycarbonyl-aminopyrimidine.

Provenance & Evidence