Water → HCID 14700561, compound

HRID 1756806Notes

Reaction equation

HRID 1756806 reaction equation
[F:1][C:2]1[C:20]([N:21]2[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]2)=[CH:19][C:5]2=[N:6][C:7]3[N:8]([CH3:18])[CH:9]=[C:10]([C:15](N)=[O:16])[C:11](=[O:14])[C:12]=3[CH:13]=[C:4]2[CH:3]=1.[OH2:28]>>[F:1][C:2]1[C:20]([N:21]2[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]2)=[CH:19][C:5]2=[N:6][C:7]3[N:8]([CH3:18])[CH:9]=[C:10]([C:15]([OH:28])=[O:16])[C:11](=[O:14])[C:12]=3[CH:13]=[C:4]2[CH:3]=1

Participants

3

Reactant 2

HCID 962WaterHCID 18994607HCID 18994607, compound

Product 1

HCID 14700561HCID 14700561, compound

Conditions

Temperature
20 °C

Procedure

7-Fluoro-8-(4-methyl-1-piperazinyl)-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid is prepared under the conditions of Application Example 2, but starting with 0.3 g of 7-fluoro-1-methyl-8-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxamide. After cooling to approximately 20° C., the reaction mixture is treated with 50 cm3 of water; the insoluble matter is drained and washed with twice 10 cm3 of water.

Workup

  1. washwashed with twice 10 cm3 of water

Sources & evidence

ORD record
ord-c657066e69f04acb9ec0b1d983e7541e
Source dataset
uspto-grants-1995_08
Patent number
US05442070

Reaction notes

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