HCID 10248180, compound → HCID 15292263, compound

HRID 1756820Notes

Reaction equation

HRID 1756820 reaction equation
[NH2:1][C:2]1[C:10]2[CH2:9][CH:8]([CH3:11])[O:7][C:6]=2[C:5]([C:12]([NH:14][CH2:15][CH2:16][C:17]23[CH2:24][CH2:23][CH2:22][N:21]2[CH2:20][CH2:19][CH2:18]3)=[O:13])=[CH:4][C:3]=1Cl>[Pd].C(O)C>[NH2:1][C:2]1[C:10]2[CH2:9][CH:8]([CH3:11])[O:7][C:6]=2[C:5]([C:12]([NH:14][CH2:15][CH2:16][C:17]23[CH2:24][CH2:23][CH2:22][N:21]2[CH2:20][CH2:19][CH2:18]3)=[O:13])=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 10248180HCID 10248180, compound

Product 1

HCID 15292263HCID 15292263, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 4-amino-N-[2-(1-azabicyclo[3.3.0]octan-5yl)ethyl]-5-chloro-2-methyl-2,3-dihydrobenzo[b]furan-7-carboxamide (100 mg) obtained by Example 2, 20% Pd-C (catalystic amount) and ethanol was stirred under hydrogen gas atmosphere for 20 hours. Then, the catalyst was removed by filtration and the solvent was distilled out in vacuo to afford the titled compound in quantitative amount.

Workup

  1. customThen, the catalyst was removed by filtration
  2. distillationthe solvent was distilled out in vacuo

Sources & evidence

ORD record
ord-4e668a2b1f3a4fa78bd4da0243e72e0a
Source dataset
uspto-grants-1995_08
Patent number
US05442077

Reaction notes

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