Diethyl methylphosphonate → HCID 11066348, compound

Participants

Reaction Steps

2.6 g (11.6 mmol) of ethyl (S)-2-(methoxycarbonylamino)-4-chlorobutanoate and 6.3 g (46.4 mmol) of diethyl methanephosphonate are stirred for 15 h at 140° C. The excess diethyl methanephosphonate is then removed at 90° C. under a high vacuum. The crude product thus obtained is produced as a colorless oil and shows no further impurities in 1H-NMR; yield: 2.8 g (82%),

Provenance & Evidence