Lithium Hydroxide → HCID 19391289, compound

Participants

Reaction Steps

To 3 g of 1-(4-cyanophenyl)-4-(methoxycarbonylmethyl)-piperazine in 46 ml of tetrahydrofuran 58 ml of a 1 molar aqueous lithium hydroxide solution are added, at ambient temperature and with stirring, and the reaction solution is left to stand for 3 hours at ambient temperature. Then 3.2 g of ammonium chloride are added and the tetrahydrofuran is distilled off under reduced pressure. The precipitate is suction filtered, washed with water and dried. Yield: 2.2 g (77% of theory), Melting point: over 300° C. Rf value: 0.18 (silica gel; methylene chloride/methanol=9:1)

Provenance & Evidence