HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-(4-Cyanophenyl)-4-[4-(methoxycarbonylmethyl)-piperidinomethyl]-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methyl (piperidin-4-yl)acetate--hydrogen chloride (1/1) | HCID 18423605 | — |
| Reactant | 1-(4-Cyanophenyl)-4-iodomethyl-piperidine | HCID 19391456 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(4-Cyanophenyl)-4-[4-(methoxycarbonylmethyl)-piperidinomethyl]-piperidine | HCID 19391546 | — |
Reaction Conditions
| Temperature | 130 °C |
|---|
Reaction Steps
A suspension of 2.18 g of 1-(4-cyanophenyl)-4-iodomethyl-piperidine (mixture from Example XXV), 1.26 g of methyl-4-piperidyl-acetate-hydrochloride and 1.35 g of triethylamine in 150 ml of dimethylformamide is heated to 130° C. for 24 hours. After cooling, the solvent is removed under reduced pressure and the residue is chromatographed over silica gel with methylene chloride/methanol (30:1). The solvent is removed under reduced pressure and the crude product is used for the next stage of synthesis without any further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05442064 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-a4f35610b9dd44dda69d7a616a37597c |
| Source note | uspto-grants-1995_08 |