Hydrochloric Acid → HCID 178479318, compound

Participants

Reaction Steps

A solution of 300 mg of 1-[4-(N-benzyloxycarbonyl-amidino)-phenyl]-4-[N-[trans-4-[(morpholinocarbonyl)-methoxycarbonyl]-cyclohexyl]-aminocarbonyl]-piperazine in 20 ml dimethylformamide is hydrogenated for 2 hours in the presence of 0.3 g of a catalyst consisting of 10% palladium on activated charcoal under an excess hydrogen pressure of 5 bar. Ethereal hydrochloric acid is added and the mixture is filtered. The filtrate is evaporated down under reduced pressure and the residue remaining is triturated with ether/acetone, acetone and acetone/methylene chloride and suction filtered. Yield: 210 mg (83% of theory), Rf value: 0.27 (silica gel; methylene chloride/methanol/conc. ammonia=4:1:0.25)

Provenance & Evidence