Potassium Iodide → HCID 145821438, compound

Participants

Reaction Steps

A suspension of 1 equivalent of 1-[4-(N-benzyloxycarbonylamidino)-phenyl]-4-[4-(carboxymethyl)-piperidinocarbonyl]-piperidine is stirred for 2 days with 2 equivalents each of chloromethyl pivalate, potassium iodide, potassium bicarbonate and potassium carbonate in dimethylformamide at ambient temperature for 2 days. After pouring into water, extraction with ethyl acetate and evaporation down of the ethyl acetate extract, the desired product is obtained which is then chromotagraphed over silica gel. The following compounds are obtained analogously to Example 10:

Provenance & Evidence