Pyridine → HCID 19389470, compound

HRID 1757047Notes

Reaction equation

HRID 1757047 reaction equation
[Si:1]([O:8][CH2:9][CH:10]1[O:15][C:14](=[O:16])[CH:13]=[C:12]([OH:17])[CH2:11]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].N1C=CC=CC=1.[C:24](Cl)(=[O:26])[CH3:25]>ClCCl>[C:24]([O:17][C:12]1[CH2:11][CH:10]([CH2:9][O:8][Si:1]([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2])[O:15][C:14](=[O:16])[CH:13]=1)(=[O:26])[CH3:25]

Participants

5

Reactant 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 67809616HCID 67809616, compound

Product 1

HCID 19389470HCID 19389470, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 6-t-butyldimethylsilyloxymethyl-5,6-dihydro-4-hydroxy-pyran-2-one (0.26 parts) in dichloromethane (3 cm3) at ambient temperature was added pyridine (0.1 parts) and then acetyl chloride (0.1 parts). After approximately 30 minutes at ambient temperature the reaction mixture was washed with water, dried over MgSO4 and evaporated to yield 4-acetoxy-6-t-butyldimethylsilyloxymethyl-5,6-dihydropyran-2-one (0.2 parts).

Workup

  1. washAfter approximately 30 minutes at ambient temperature the reaction mixture was washed with water
  2. dry with materialdried over MgSO4
  3. customevaporated

Sources & evidence

ORD record
ord-cc4c16edcc854448b5c8b86d690ffaff
Source dataset
uspto-grants-1995_08
Patent number
US05443970

Reaction notes

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