Dimethylformamide → HCID 178518676, compound

Participants

Reaction Steps

To a stirred solution of 20 mmole of 3-hydroxypicolinamide (2.6 g) in 10 mL dimethylformamide is added 3.2 g (20 mmole) of isatoic anhydride. The mixture is heated to 80°-100° C. and then 5 mg of powdered potassium hydroxide is added. The mixture is kept at this temperature for 4 hours then cooled and the precipitate is isolated, washed with cold dimethylformamide and methanol. Yield: 2.2 g (46%); mp: 190°-192° C. Color of fluorescence: blue.

Provenance & Evidence