反应详情

温度

24 °C

A mixture of 2.90 g (6.10 mmol) of 2-{4-[4-(4,5-dichloro-2-methylimidazol-1-yl )butyl]-1-piperazinyl}-5-benzyloxypyrimidine and 0.30 g of 10% palladium on carbon in 50 ml of methanol is stirred for 12 hours under a hydrogen atmosphere at room temperature (24° C.) and at a pressure of 0.28 MPa. After filtration, washing with methanol and evaporation to dryness, the product is chromatographed on silica gel, yielding 1.39 g (59%) of 2-{4-[4-(4,5-dichloro-2-methylimidazol -1-yl)butyl]-1-piperazinyl}-5-hydroxypyrimidine with a melting point of 154°-6° C.

1. filtrationAfter filtration
2. washwashing with methanol and evaporation to dryness
3. customthe product is chromatographed on silica gel