Methanol → Methyl 2-(3-bromophenyl)acetate

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Reaction Steps

3-Bromophenyl acetic acid (2.0 g, 9.3 mmol) was dissolved in methanol (20 ml) in a 50 ml flask. Concentrated sulfuric acid (2 drops) was added, and the mixture was refluxed under nitrogen for ten hours then concentrated under reduced pressure. The residue was mixed with dichloromethane (20 ml) and saturated sodium bicarbonate solution (10 ml). The organic material was separated, dried (MgSO4) and concentrated under reduced pressure. The residue was flushed through silica gel with hexane/ethyl acetate (3:1), and concentrated to provide 2.12 g (99%) of methyl (3-bromophenyl)acetate, which was used without further purification.

Provenance & Evidence