Sodium Methoxide → methyl 2-AMINO-1-CYCLOHEXENE-1-CARBOXYLATE

HRID 1757094Notes

Reaction equation

C(OC([NH:6][C:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=1[C:13]([O:15][CH2:16]C)=[O:14])=O)C.C[O-].[Na+]>>[NH2:6][C:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=1[C:13]([O:15][CH3:16])=[O:14]

Participants

Reactant 2

HCID 10942334Sodium Methoxide

HCID 54524467HCID 54524467, compound

Product 1

HCID 2724961methyl 2-AMINO-1-CYCLOHEXENE-1-CARBOXYLATEYield 77.1%

Procedure

Using the method of Example 1 Part B, ethyl 2-[(ethoxycarbonyl)amino]-1-cyclohexene-1-carboxylate (158 g, 0.66 mole) was reacted with sodium methoxide to provide 79 g of methyl 2-amino-1-cyclohexene-1-carboxylate as a white solid.

Sources & evidence

ORD record: ord-0689846546b3441f92e529bf6ded0ed8
Source dataset: uspto-grants-1995_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05444065

Reaction notes

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